Item Type | Name |
Concept
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Protein-Tyrosine Kinases
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Concept
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Protein Binding
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Concept
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Protein Processing, Post-Translational
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Concept
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Protein Kinases
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Concept
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Protein Biosynthesis
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Concept
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Protein Subunits
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Concept
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Protein Structure, Tertiary
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Concept
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Ubiquitin-Protein Ligase Complexes
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Concept
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DNA-Activated Protein Kinase
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Concept
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Protein Transport
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Concept
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Protein Interaction Mapping
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Concept
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Mitogen-Activated Protein Kinase Kinases
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Concept
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SUMO-1 Protein
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Concept
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Ubiquitin-Protein Ligases
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Concept
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Retinoblastoma-Binding Protein 1
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Concept
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Protein Interaction Domains and Motifs
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Concept
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CDC2 Protein Kinase
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Concept
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Herpes Simplex Virus Protein Vmw65
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Concept
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Cyclic AMP-Dependent Protein Kinase Type II
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Concept
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bcl-Associated Death Protein
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Concept
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Protein Phosphatase 2
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Concept
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Protein Stability
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Concept
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Cyclic AMP-Dependent Protein Kinases
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Concept
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Protein Isoforms
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Concept
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Protein Kinase Inhibitors
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Concept
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p38 Mitogen-Activated Protein Kinases
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Academic Article
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The herpes simplex virus 1 U(L)34 protein interacts with a cytoplasmic dynein intermediate chain and targets nuclear membrane.
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Academic Article
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The essential protein encoded by the UL31 gene of herpes simplex virus 1 depends for its stability on the presence of UL34 protein.
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Academic Article
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Redefining virology.
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Academic Article
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Role of cyclin D3 in the biology of herpes simplex virus 1 ICPO.
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Academic Article
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Bcl-2 blocks a caspase-dependent pathway of apoptosis activated by herpes simplex virus 1 infection in HEp-2 cells.
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Academic Article
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Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence.
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Academic Article
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An early regulatory function required in a cell type-dependent manner is expressed by the genomic but not the cDNA copy of the herpes simplex virus 1 gene encoding infected cell protein 0.
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Academic Article
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E2F proteins are posttranslationally modified concomitantly with a reduction in nuclear binding activity in cells infected with herpes simplex virus 1.
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Academic Article
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Posttranslational processing of infected cell protein 22 mediated by viral protein kinases is sensitive to amino acid substitutions at distant sites and can be cell-type specific.
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Academic Article
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Herpes simplex virus 1 alpha regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1.
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Academic Article
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RNAs extracted from herpes simplex virus 1 virions: apparent selectivity of viral but not cellular RNAs packaged in virions.
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Academic Article
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The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins.
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Academic Article
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cdc2 cyclin-dependent kinase binds and phosphorylates herpes simplex virus 1 U(L)42 DNA synthesis processivity factor.
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Academic Article
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Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts.
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Academic Article
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The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity.
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Academic Article
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The role of cdc2 in the expression of herpes simplex virus genes.
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Academic Article
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Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes.
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Academic Article
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Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes.
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Academic Article
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U(S)3 protein kinase of herpes simplex virus 1 blocks caspase 3 activation induced by the products of U(S)1.5 and U(L)13 genes and modulates expression of transduced U(S)1.5 open reading frame in a cell type-specific manner.
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Academic Article
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Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects.
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Academic Article
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The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a.
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Academic Article
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Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0.
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Academic Article
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Requirements for the nuclear-cytoplasmic translocation of infected-cell protein 0 of herpes simplex virus 1.
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Academic Article
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Herpes simplex virus 1 gene expression is accelerated by inhibitors of histone deacetylases in rabbit skin cells infected with a mutant carrying a cDNA copy of the infected-cell protein no. 0.
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Academic Article
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Activation of NF-kappaB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis.
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Academic Article
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The U(S)3 protein kinase blocks apoptosis induced by the d120 mutant of herpes simplex virus 1 at a premitochondrial stage.
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Academic Article
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Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1.
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Academic Article
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Posttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localize.
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Academic Article
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Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity.
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Academic Article
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Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis.
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Academic Article
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Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites.
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Academic Article
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Infected cell protein No. 22 is subject to proteolytic cleavage by caspases activated by a mutant that induces apoptosis.
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Academic Article
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The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs.
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Academic Article
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The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1.
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Academic Article
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Herpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functions.
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Academic Article
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The first 30 minutes in the life of a virus: unREST in the nucleus.
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Academic Article
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Protein kinase B/Akt is present in activated form throughout the entire replicative cycle of deltaU(S)3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1.
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Academic Article
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Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces.
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Academic Article
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Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1.
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Academic Article
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The U(L)41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins.
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Academic Article
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Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses.
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Academic Article
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State and role of SRC family kinases in replication of herpes simplex virus 1.
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Academic Article
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U(S)3 and U(S)3.5 protein kinases of herpes simplex virus 1 differ with respect to their functions in blocking apoptosis and in virion maturation and egress.
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Academic Article
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The virion host shutoff protein (UL41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase A.
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Academic Article
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Separation of receptor-binding and profusogenic domains of glycoprotein D of herpes simplex virus 1 into distinct interacting proteins.
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Academic Article
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Mapping of key functions of the herpes simplex virus 1 U(S)3 protein kinase: the U(S)3 protein can form functional heteromultimeric structures derived from overlapping truncated polypeptides.
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Academic Article
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In transduced cells, the US3 protein kinase of herpes simplex virus 1 precludes activation and induction of apoptosis by transfected procaspase 3.
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Academic Article
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Temperature-sensitive mutations in the putative herpes simplex virus type 1 terminase subunits pUL15 and pUL33 preclude viral DNA cleavage/packaging and interaction with pUL28 at the nonpermissive temperature.
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Academic Article
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Expression of gamma interferon-dependent genes is blocked independently by virion host shutoff RNase and by US3 protein kinase.
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Academic Article
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Replication-competent herpes simplex virus 1 isolates selected from cells transfected with a bacterial artificial chromosome DNA lacking only the UL49 gene vary with respect to the defect in the UL41 gene encoding host shutoff RNase.
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Academic Article
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Role of cdk9 in the optimization of expression of the genes regulated by ICP22 of herpes simplex virus 1.
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Academic Article
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Translocation and colocalization of ICP4 and ICP0 in cells infected with herpes simplex virus 1 mutants lacking glycoprotein E, glycoprotein I, or the virion host shutoff product of the UL41 gene.
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Academic Article
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Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells.
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Academic Article
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The interaction of herpes simplex virus 1 regulatory protein ICP22 with the cdc25C phosphatase is enabled in vitro by viral protein kinases US3 and UL13.
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Academic Article
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Interwoven roles of cyclin D3 and cdk4 recruited by ICP0 and ICP4 in the expression of herpes simplex virus genes.
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Academic Article
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Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA.
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Academic Article
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Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex.
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Academic Article
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Modulation of vascular remodeling induced by a brief intraluminal exposure to the recombinant R7020 strain of Herpes simplex-1.
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Academic Article
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The histone acetyltransferase CLOCK is an essential component of the herpes simplex virus 1 transcriptome that includes TFIID, ICP4, ICP27, and ICP22.
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Academic Article
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The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem.
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Academic Article
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US3 protein kinase of HSV-1 cycles between the cytoplasm and nucleus and interacts with programmed cell death protein 4 (PDCD4) to block apoptosis.
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Academic Article
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Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression.
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Academic Article
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Overexpression of the ubiquitin-specific protease 7 resulting from transfection or mutations in the ICP0 binding site accelerates rather than depresses herpes simplex virus 1 gene expression.
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Academic Article
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Role of cellular phosphatase cdc25C in herpes simplex virus 1 replication.
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Academic Article
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During its nuclear phase the multifunctional regulatory protein ICP0 undergoes proteolytic cleavage characteristic of polyproteins.
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Academic Article
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The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes.
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Academic Article
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Small dense nuclear bodies are the site of localization of herpes simplex virus 1 U(L)3 and U(L)4 proteins and of ICP22 only when the latter protein is present.
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Academic Article
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Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins.
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Academic Article
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The herpes simplex virus 1 US3 protein kinase blocks caspase-dependent double cleavage and activation of the proapoptotic protein BAD.
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Academic Article
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Oct-1 is posttranslationally modified and exhibits reduced capacity to bind cognate sites at late times after infection with herpes simplex virus 1.
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Academic Article
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Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells.
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Academic Article
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ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression.
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Academic Article
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Nuclear retention of ICP0 in cells exposed to HDAC inhibitor or transfected with DNA before infection with herpes simplex virus 1.
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Academic Article
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Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1.
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Academic Article
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ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells.
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Academic Article
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Role of herpes simplex virus ICP0 in the transactivation of genes introduced by infection or transfection: a reappraisal.
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Academic Article
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The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1.
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Academic Article
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Use of biotinylated plasmid DNA as a surrogate for HSV DNA to identify proteins that repress or activate viral gene expression.
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Academic Article
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Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.
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Academic Article
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RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation.
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Academic Article
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Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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Academic Article
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The nuclear-cytoplasmic shuttling of virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU-rich and stable cellular mRNAs.
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Academic Article
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Tristetraprolin Recruits the Herpes Simplex Virion Host Shutoff RNase to AU-Rich Elements in Stress Response mRNAs To Enable Their Cleavage.
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Academic Article
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HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase, and cell derivation.
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Academic Article
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The stability of herpes simplex virus 1 ICP0 early after infection is defined by the RING finger and the UL13 protein kinase.
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Academic Article
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PML plays both inimical and beneficial roles in HSV-1 replication.
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Academic Article
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The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartments.
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Concept
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Promyelocytic Leukemia Protein
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Concept
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DEAD Box Protein 58
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Grant
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MOLECULAR BIOLOGY OF HERPES SIMPLEX VIRUSES
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Grant
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DISSECTION OF THE FUNCTIONS OF HERPES SIMPLEX VIRUS ICPO
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Grant
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FUNCTIONS FOR HERPES SIMPLEX VIRUS ICP22 AND US1.5
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Grant
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Selective Degradation of mRNA by Herpes Simplex Virus 1
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Grant
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The functions of the US3 protein kinase of herpes simplex virus
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Grant
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Dissection of the Functions of Herpes Simplex Virus ICPO
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Grant
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UCCRC: VIRAL ONCOLOGY PROGRAM
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Grant
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CONFERENCE ON CONTROL OF VIRAL LATENCY AND PERSISTENCE
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Grant
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MECHANISMS OF VIRAL INFECTION IN RELATION TO CANCER
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Grant
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HERPES SIMPLEX VIRUS MULTIPLICATION
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